| Title : Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors - Urbain_2004_Planta.Med_70_1011 |
| Author(s) : Urbain A , Marston A , Queiroz EF , Ndjoko K , Hostettmann K |
| Ref : Planta Med , 70 :1011 , 2004 |
|
Abstract :
In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity. A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norswertianolin), and bellidifolin 8-O-beta-glucopyranoside (swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay. |
| PubMedSearch : Urbain_2004_Planta.Med_70_1011 |
| PubMedID: 15490334 |
Urbain A, Marston A, Queiroz EF, Ndjoko K, Hostettmann K (2004)
Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors
Planta Med
70 :1011
Urbain A, Marston A, Queiroz EF, Ndjoko K, Hostettmann K (2004)
Planta Med
70 :1011