Title : A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense - Van Arnam_2015_J.Am.Chem.Soc_137_14272 |
Author(s) : Van Arnam EB , Ruzzini AC , Sit CS , Currie CR , Clardy J |
Ref : Journal of the American Chemical Society , 137 :14272 , 2015 |
Abstract :
Bacterial symbionts of fungus-growing ants occupy a highly specialized ecological niche and face the constant existential threat of displacement by another strain of ant-adapted bacteria. As part of a systematic study of the small molecules underlying this fraternal competition, we discovered an analog of the antitumor agent rebeccamycin, a member of the increasingly important indolocarbazole family. While several gene clusters consistent with this molecule's newly reported modification had previously been identified in metagenomic studies, the metabolite itself has been cryptic. The biosynthetic gene cluster for 9-methoxyrebeccamycin is encoded on a plasmid in a manner reminiscent of plasmid-derived peptide antimicrobials that commonly mediate antagonism among closely related Gram-negative bacteria. |
PubMedSearch : Van Arnam_2015_J.Am.Chem.Soc_137_14272 |
PubMedID: 26535611 |
Gene_locus related to this paper: 9pseu-a0a0p0s8v9 |
Gene_locus | 9pseu-a0a0p0s8v9 |
Van Arnam EB, Ruzzini AC, Sit CS, Currie CR, Clardy J (2015)
A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense
Journal of the American Chemical Society
137 :14272
Van Arnam EB, Ruzzini AC, Sit CS, Currie CR, Clardy J (2015)
Journal of the American Chemical Society
137 :14272