Van Arnam_2015_J.Am.Chem.Soc_137_14272

Reference

Title : A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense - Van Arnam_2015_J.Am.Chem.Soc_137_14272
Author(s) : Van Arnam EB , Ruzzini AC , Sit CS , Currie CR , Clardy J
Ref : Journal of the American Chemical Society , 137 :14272 , 2015
Abstract :

Bacterial symbionts of fungus-growing ants occupy a highly specialized ecological niche and face the constant existential threat of displacement by another strain of ant-adapted bacteria. As part of a systematic study of the small molecules underlying this fraternal competition, we discovered an analog of the antitumor agent rebeccamycin, a member of the increasingly important indolocarbazole family. While several gene clusters consistent with this molecule's newly reported modification had previously been identified in metagenomic studies, the metabolite itself has been cryptic. The biosynthetic gene cluster for 9-methoxyrebeccamycin is encoded on a plasmid in a manner reminiscent of plasmid-derived peptide antimicrobials that commonly mediate antagonism among closely related Gram-negative bacteria.

PubMedSearch : Van Arnam_2015_J.Am.Chem.Soc_137_14272
PubMedID: 26535611
Gene_locus related to this paper: 9pseu-a0a0p0s8v9

Related information

Gene_locus 9pseu-a0a0p0s8v9

Citations formats

Van Arnam EB, Ruzzini AC, Sit CS, Currie CR, Clardy J (2015)
A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense
Journal of the American Chemical Society 137 :14272

Van Arnam EB, Ruzzini AC, Sit CS, Currie CR, Clardy J (2015)
Journal of the American Chemical Society 137 :14272