Title : Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease - Van Dam_2008_Psychopharmacology.(Berl)_197_37 |
Author(s) : Van Dam D , Coen K , De Deyn PP |
Ref : Psychopharmacology (Berl) , 197 :37 , 2008 |
Abstract :
RATIONALE: The interest for acetylcholinesterase inhibitors in the treatment of Alzheimer's disease has been greatly renewed owing to the discovery of a broad range of additional cholinergic and non-cholinergic effects, exploitable to maximize the efficacy of these drugs beyond merely improving intellectual functions at the symptomatic level. OBJECTIVES: The age-dependent cognitive decline in the valid APP23 transgenic mouse model for Alzheimer's disease was employed to evaluate disease-modifying efficacy of chronic treatment with donepezil. MATERIALS AND |
PubMedSearch : Van Dam_2008_Psychopharmacology.(Berl)_197_37 |
PubMedID: 18008065 |
Van Dam D, Coen K, De Deyn PP (2008)
Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease
Psychopharmacology (Berl)
197 :37
Van Dam D, Coen K, De Deyn PP (2008)
Psychopharmacology (Berl)
197 :37