Vanin_2022_Sci.Rep_12_15376

Reference

Title : Neuroprotective potential of Cannabis sativa-based oils in Caenorhabditis elegans - Vanin_2022_Sci.Rep_12_15376
Author(s) : Vanin AP , Tamagno WA , Alves C , Mesacasa L , Santin LF , Sutorillo NT , Bilibio D , Muller C , Galon L , Kaizer RR
Ref : Sci Rep , 12 :15376 , 2022
Abstract :

Substances from the Cannabis sativa species, especially cannabidiol (CBD) and Delta-9-tetrahydrocannabinol (delta9-THC), have attracted medical attention in recent years. The actions of these two main cannabinoids modulate the cholinergic nervous system (CholNS) involving development, synaptic plasticity, and response to endogenous and environmental damage, as a characteristic of many neurodegenerative diseases. The dynamics of these diseases are mediated by specific neurotransmitters, such as the GABAergic nervous system (GNS) and the CholNS. The nematode Caenorhabditis elegans is an important experimental model, which has different neurotransmitter systems that coordinate its behavior and has a transgene strain that encodes the human beta-amyloid 1-42 peptide in body wall muscle, one of the main proteins involved in Alzheimers disease. Therefore, the objective of this study was to evaluate the protective potential of terpenoids found in C. sativa in the GNS and CholNS of C. elegans. The effect of two C. sativa oils with variations in CBD and THC concentrations on acetylcholinesterase (AChE) activity, lipid peroxidation, and behavior of C. elegans was evaluated. C. sativa oils were efficient in increasing pharyngeal pumping rate and reducing defecation cycle, AChE activity, and ROS levels in N2 strains. In the muscle:Abeta1-42 strain, mainly when using CBD oil, worm movement, body bends, and pharyngeal pumping were increased, with a reduced AChE activity. Consequently, greater investments in scientific research are needed, in addition to breaking the taboo on the use of the C. sativa plant as an alternative for medicinal use, especially in neurodegenerative diseases, which have already shown positive initial results.

PubMedSearch : Vanin_2022_Sci.Rep_12_15376
PubMedID: 36100636

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Citations formats

Vanin AP, Tamagno WA, Alves C, Mesacasa L, Santin LF, Sutorillo NT, Bilibio D, Muller C, Galon L, Kaizer RR (2022)
Neuroprotective potential of Cannabis sativa-based oils in Caenorhabditis elegans
Sci Rep 12 :15376

Vanin AP, Tamagno WA, Alves C, Mesacasa L, Santin LF, Sutorillo NT, Bilibio D, Muller C, Galon L, Kaizer RR (2022)
Sci Rep 12 :15376