| Title : Kinetics of Chemical Processes in the Human Brain. Proton Blockade of Acetylcholinesterase and pH-Impulse in the Mechanism of Functioning of the Cholinergic Synapse - Varfolomeev_2020_Dokl.Biochem.Biophys_491_85 |
| Author(s) : Varfolomeev SD , Bykov VI , Tsybenova SB |
| Ref : Dokl Biochem Biophys , 491 :85 , 2020 |
|
Abstract :
A kinetic model describing the dynamics of synaptic "discharge" taking into account the kinetics of the injection of the neurotransmitter into the synaptic cleft, the pH-dependence of the catalytic activity of the enzyme, and diffusion withdrawal of protons is proposed. The model provides a physicochemical explanation for a number of important physiological phenomena, such as the neuromuscular paralysis, the molecular mechanism of neurological memory, and the effect of some neurotoxins and drugs. |
| PubMedSearch : Varfolomeev_2020_Dokl.Biochem.Biophys_491_85 |
| PubMedID: 32483758 |
Varfolomeev SD, Bykov VI, Tsybenova SB (2020)
Kinetics of Chemical Processes in the Human Brain. Proton Blockade of Acetylcholinesterase and pH-Impulse in the Mechanism of Functioning of the Cholinergic Synapse
Dokl Biochem Biophys
491 :85
Varfolomeev SD, Bykov VI, Tsybenova SB (2020)
Dokl Biochem Biophys
491 :85