Varoqueaux_2006_Neuron_51_741

Reference

Title : Neuroligins determine synapse maturation and function - Varoqueaux_2006_Neuron_51_741
Author(s) : Varoqueaux F , Aramuni G , Rawson RL , Mohrmann R , Missler M , Gottmann K , Zhang W , Sudhof TC , Brose N
Ref : Neuron , 51 :741 , 2006
Abstract :

Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism. We show that deletion mutant mice lacking neuroligin expression die shortly after birth due to respiratory failure. This respiratory failure is a consequence of reduced GABAergic/glycinergic and glutamatergic synaptic transmission and network activity in brainstem centers that control respiration. However, the density of synaptic contacts is not altered in neuroligin-deficient brains and cultured neurons. Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts.

PubMedSearch : Varoqueaux_2006_Neuron_51_741
PubMedID: 16982420

Related information

Citations formats

Varoqueaux F, Aramuni G, Rawson RL, Mohrmann R, Missler M, Gottmann K, Zhang W, Sudhof TC, Brose N (2006)
Neuroligins determine synapse maturation and function
Neuron 51 :741

Varoqueaux F, Aramuni G, Rawson RL, Mohrmann R, Missler M, Gottmann K, Zhang W, Sudhof TC, Brose N (2006)
Neuron 51 :741