| Title : Ancient noncoding elements conserved in the human genome - Venkatesh_2006_Science_314_1892 |
| Author(s) : Venkatesh B , Kirkness EF , Loh YH , Halpern AL , Lee AP , Johnson J , Dandona N , Viswanathan LD , Tay A , Venter JC , Strausberg RL , Brenner S |
| Ref : Science , 314 :1892 , 2006 |
|
Abstract :
Cartilaginous fishes represent the living group of jawed vertebrates that diverged from the common ancestor of human and teleost fish lineages about 530 million years ago. We generated approximately 1.4x genome sequence coverage for a cartilaginous fish, the elephant shark (Callorhinchus milii), and compared this genome with the human genome to identify conserved noncoding elements (CNEs). The elephant shark sequence revealed twice as many CNEs as were identified by whole-genome comparisons between teleost fishes and human. The ancient vertebrate-specific CNEs in the elephant shark and human genomes are likely to play key regulatory roles in vertebrate gene expression. |
| PubMedSearch : Venkatesh_2006_Science_314_1892 |
| PubMedID: 17185593 |
| Gene_locus related to this paper: calmi-a0a4w3h3v0 , calmi-a0a4w3hel5 , calmi-v9krf6 |
| Gene_locus | calmi-a0a4w3h3v0 calmi-a0a4w3hel5 calmi-v9krf6 |
| Gene_locus_frgt | calmi-v9lgm2 |
Venkatesh B, Kirkness EF, Loh YH, Halpern AL, Lee AP, Johnson J, Dandona N, Viswanathan LD, Tay A, Venter JC, Strausberg RL, Brenner S (2006)
Ancient noncoding elements conserved in the human genome
Science
314 :1892
Venkatesh B, Kirkness EF, Loh YH, Halpern AL, Lee AP, Johnson J, Dandona N, Viswanathan LD, Tay A, Venter JC, Strausberg RL, Brenner S (2006)
Science
314 :1892