| Title : Multicomponent Synthesis of S-Benzyl Dithiocarbamates from para-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer's Disease - Venkatesh_2022_J.Org.Chem_87_6730 |
| Author(s) : Venkatesh R , Shankar G , Narayanan AC , Modi G , Sabiah S , Kandasamy J |
| Ref : J Org Chem , 87 :6730 , 2022 |
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Abstract :
Multicomponent synthesis of biologically relevant S-benzyl dithiocarbamates from para-quinone methides, amines, and carbon disulfide are described under catalyst and additive-free conditions. The reactions proceeded at room temperature in a short span of time with excellent yields. One of the synthesized compounds, 3e showed considerable acetylcholinesterase (AChE) inhibitory (51.70 + 5.63% at 20 microm) and antioxidant (63.52 +/- 1.15 at 20 microm) activities. |
| PubMedSearch : Venkatesh_2022_J.Org.Chem_87_6730 |
| PubMedID: 35545917 |
Venkatesh R, Shankar G, Narayanan AC, Modi G, Sabiah S, Kandasamy J (2022)
Multicomponent Synthesis of S-Benzyl Dithiocarbamates from para-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer's Disease
J Org Chem
87 :6730
Venkatesh R, Shankar G, Narayanan AC, Modi G, Sabiah S, Kandasamy J (2022)
J Org Chem
87 :6730