Verhage_2000_Science_287_864

Reference

Title : Synaptic assembly of the brain in the absence of neurotransmitter secretion - Verhage_2000_Science_287_864
Author(s) : Verhage M , Maia AS , Plomp JJ , Brussaard AB , Heeroma JH , Vermeer H , Toonen RF , Hammer RE , van den Berg TK , Missler M , Geuze HJ , Sudhof TC
Ref : Science , 287 :864 , 2000
Abstract :

Brain function requires precisely orchestrated connectivity between neurons. Establishment of these connections is believed to require signals secreted from outgrowing axons, followed by synapse formation between selected neurons. Deletion of a single protein, Munc18-1, in mice leads to a complete loss of neurotransmitter secretion from synaptic vesicles throughout development. However, this does not prevent normal brain assembly, including formation of layered structures, fiber pathways, and morphologically defined synapses. After assembly is completed, neurons undergo apoptosis, leading to widespread neurodegeneration. Thus, synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does. Neurotransmitter secretion probably functions to validate already established synaptic connections.

PubMedSearch : Verhage_2000_Science_287_864
PubMedID: 10657302

Related information

Citations formats

Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van den Berg TK, Missler M, Geuze HJ, Sudhof TC (2000)
Synaptic assembly of the brain in the absence of neurotransmitter secretion
Science 287 :864

Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van den Berg TK, Missler M, Geuze HJ, Sudhof TC (2000)
Science 287 :864