Villarroel_2001_J.Physiol_532_175

Single-channel recording from visualised endplates in freshly dissociated muscles from postnatal and denervated rat muscle revealed the presence of a low conductance, fetal type of acetylcholine receptor. Kinetic analysis showed a main component in the burst durations with a mean of 10.8 +/- 2.7 ms (n = 29). Receptors from female rats had an additional 27.3 +/- 5.5 ms (n = 5) kinetic component which was found in one-third of the 15 female endplates. Recordings from male and female denervated muscles gave more homogeneous kinetics with single time constants of 7.2 +/- 1.3 and 7.4 +/- 1.3 ms, respectively. It is concluded that the acetylcholine receptor channels present during early development are different from those of denervated muscle.