Waldeck_1988_Agents.Actions.Suppl_23_55

Reference

Title : New possibilities for the beta-adrenoceptor agonist bronchodilator drugs - Waldeck_1988_Agents.Actions.Suppl_23_55
Author(s) : Waldeck B , Olsson OA , Svensson LA
Ref : Agents Actions Suppl , 23 :55 , 1988
Abstract :

The pharmacological basis of the selectivity of bronchodilator beta-adrenoceptor agonists is discussed. Functional selectivity depends on both drug-related and tissue-related factors. Extensive enlargement of the beta-adrenoceptor agonist molecules permits interaction with hypothetical exoreceptor sites. A soft drug inhaled for local effects and which subsequently is inactivated by biotransformation, may give a minimum of systemic side effects. Conversely, a prodrug which requires metabolic activation offers new possibilities to alter the pharmacokinetic properties of a beta-adrenoceptor agonist. Several new compounds with interesting properties are presently subject to clinical trials.

PubMedSearch : Waldeck_1988_Agents.Actions.Suppl_23_55
PubMedID: 2902766

Related information

Citations formats

Waldeck B, Olsson OA, Svensson LA (1988)
New possibilities for the beta-adrenoceptor agonist bronchodilator drugs
Agents Actions Suppl 23 :55

Waldeck B, Olsson OA, Svensson LA (1988)
Agents Actions Suppl 23 :55