| Title : Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2',2'-diphenylpropionoxymethyl) pyridinium - Wang_2005_Bioorg.Med.Chem.Lett_15_4510 |
| Author(s) : Wang JQ , Miller MA , Mock BH , Lopshire JC , Groh WJ , Zipes DP , Hutchins GD , Zheng QH |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :4510 , 2005 |
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Abstract :
A new AChE tracer N-[(11)C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2',2'-diphenylpropionoxymethy l)pyridinium ([(11)C]MDDP, [(11)C]1) has been synthesized in 40-65% radiochemical yield. Initial PET dynamic studies of [(11)C]MDDP in rat heart showed rapid heart uptake and blood pool clearance to give high-quality heart images. Blocking studies of [(11)C]MDDP with pretreatment drug neostigmine in rats found only minor reductions in rat heart [(11)C]MDDP retention. The results suggest that [(11)C]MDDP delineates the heart very clearly, and the uptakes of [(11)C]MDDP in rat heart might be related to non-specific binding. |
| PubMedSearch : Wang_2005_Bioorg.Med.Chem.Lett_15_4510 |
| PubMedID: 16112863 |
| Inhibitor | Pyridophen-10 |
Wang JQ, Miller MA, Mock BH, Lopshire JC, Groh WJ, Zipes DP, Hutchins GD, Zheng QH (2005)
Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2',2'-diphenylpropionoxymethyl) pyridinium
Bioorganic & Medicinal Chemistry Lett
15 :4510
Wang JQ, Miller MA, Mock BH, Lopshire JC, Groh WJ, Zipes DP, Hutchins GD, Zheng QH (2005)
Bioorganic & Medicinal Chemistry Lett
15 :4510