| Title : Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea - Wang_2007_Org.Lett_9_5279 |
| Author(s) : Wang YH , Gao S , Yang FM , Sun QY , Wang JS , Liu HY , Li CS , Di YT , Li SL , He HP , Hao XJ |
| Ref : Org Lett , 9 :5279 , 2007 |
|
Abstract :
Hostasinine A (1), a benzylphenethylamine alkaloid with an unprecedented skeleton featuring a C-4-C-6 linkage and a nitrone moiety, was isolated from Hosta plantaginea. Its structure was established on the basis of spectroscopic data, and was further confirmed by single-crystal X-ray diffraction. The alkaloid was postulated biogenetically from haemanthidine via N-oxidation and aza-aldol-type condensation and was synthesized biomimetically. The inhibitory activities of 1 on acetylcholinesterase (AChE) and two tumor cell lines (K562 and A549) were also evaluated. |
| PubMedSearch : Wang_2007_Org.Lett_9_5279 |
| PubMedID: 17994756 |
Wang YH, Gao S, Yang FM, Sun QY, Wang JS, Liu HY, Li CS, Di YT, Li SL, He HP, Hao XJ (2007)
Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea
Org Lett
9 :5279
Wang YH, Gao S, Yang FM, Sun QY, Wang JS, Liu HY, Li CS, Di YT, Li SL, He HP, Hao XJ (2007)
Org Lett
9 :5279