Wang_2008_Science_322_957

Reference

Title : Fat metabolism links germline stem cells and longevity in C. elegans - Wang_2008_Science_322_957
Author(s) : Wang MC , O'Rourke EJ , Ruvkun G
Ref : Science , 322 :957 , 2008
Abstract :

Fat metabolism, reproduction, and aging are intertwined regulatory axes; however, the mechanism by which they are coupled remains poorly understood. We found that germline stem cells (GSCs) actively modulate lipid hydrolysis in Caenorhabditis elegans, which in turn regulates longevity. GSC arrest promotes systemic lipolysis via induction of a specific fat lipase. Subsequently, fat mobilization is promoted and life span is prolonged. Constitutive expression of this lipase in fat storage tissue generates lean and long-lived animals. This lipase is a key factor in the lipid hydrolysis and increased longevity that are induced by decreased insulin signaling. These results suggest a link between C. elegans fat metabolism and longevity.

PubMedSearch : Wang_2008_Science_322_957
PubMedID: 18988854
Gene_locus related to this paper: caeel-K04A8.5

Related information

Gene_locus caeel-K04A8.5

Citations formats

Wang MC, O'Rourke EJ, Ruvkun G (2008)
Fat metabolism links germline stem cells and longevity in C. elegans
Science 322 :957

Wang MC, O'Rourke EJ, Ruvkun G (2008)
Science 322 :957