| Title : Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases - Wang_2012_J.Med.Chem_55_3588 |
| Author(s) : Wang Y , Guan XL , Wu PF , Wang CM , Cao H , Li L , Guo XJ , Wang F , Xie N , Jiang FC , Chen JG |
| Ref : Journal of Medicinal Chemistry , 55 :3588 , 2012 |
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Abstract :
Cooperating mercapto groups with tacrine in a single molecular, novel multifunctional compounds have been designed and synthesized. These mercapto-tacrine derivatives displayed a synergistic pharmacological profile of long-term potentiation enhancement, cholinesterase inhibition, neuroprotection, and less hepatotoxicity, emerging as promising molecules for the therapy of age-related neurodegenerative diseases. |
| PubMedSearch : Wang_2012_J.Med.Chem_55_3588 |
| PubMedID: 22420827 |
Wang Y, Guan XL, Wu PF, Wang CM, Cao H, Li L, Guo XJ, Wang F, Xie N, Jiang FC, Chen JG (2012)
Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases
Journal of Medicinal Chemistry
55 :3588
Wang Y, Guan XL, Wu PF, Wang CM, Cao H, Li L, Guo XJ, Wang F, Xie N, Jiang FC, Chen JG (2012)
Journal of Medicinal Chemistry
55 :3588