| Title : A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam - Wang_2017_Nat.Prod.Res__1 |
| Author(s) : Wang YL , Zhao JC , Liang JH , Tian XG , Huo XK , Feng L , Ning J , Wang C , Zhang BJ , Chen G , Li N , Sun CP |
| Ref : Nat Prod Res , :1 , 2017 |
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Abstract :
A new protostane-type triterpenoid, 5beta,29-dihydroxy alisol A (1) was isolated from Alisma plantago-aquatica subsp. orientale (Sam.) Sam. as well as 12-deoxyphorbol-13alpha-pentadecanoate (2). We first report the presence of compound 2 in the genus Alisma. Their structures were established on the basis of 1D and 2D NMR, and HRESIMS spectroscopic analyses. All the isolated compounds were assayed for their inhibitory effects against human carboxylesterase 2 (HCE-2). Compounds 1 and 2 displayed inhibitory activities against HCE-2 with IC50 values of 29.2 and 4.6 muM, respectively. The interaction mechanisms of HCE-2 with compounds 1 and 2 were investigated by molecular docking, respectively. |
| PubMedSearch : Wang_2017_Nat.Prod.Res__1 |
| PubMedID: 29183156 |
Wang YL, Zhao JC, Liang JH, Tian XG, Huo XK, Feng L, Ning J, Wang C, Zhang BJ, Chen G, Li N, Sun CP (2017)
A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam
Nat Prod Res
:1
Wang YL, Zhao JC, Liang JH, Tian XG, Huo XK, Feng L, Ning J, Wang C, Zhang BJ, Chen G, Li N, Sun CP (2017)
Nat Prod Res
:1