| Title : Inducing secondary metabolite production from Daldinia eschscholzii JC-15 by red ginseng medium - Wang_2019_Nat.Prod.Res__1 |
| Author(s) : Wang BY , Yang YB , Yang XQ , Zhu CH , Yang S , Xu TT , Wang XY , Tan NH , Zhou H , Ding ZT |
| Ref : Nat Prod Res , :1 , 2019 |
|
Abstract :
Red ginseng (RG) is one of the most popular herbal medicines and used as a dietary supplement in recent years. The bioactive ingredient in RG can induce the production of novel microbial metabolite from fermented RG. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from Daldinia eschscholzii JC-15 cultured in red ginseng medium led to the isolation of an unprecedented benzopyran-naphthalene hybrid, daldinsin (1) and a new lactone (2). In this research, a new lactone, 8-hydroxylhelicascolide A (2) instead of helicascolide A was produced by the D. eschscholzii JC-15 induced by the red ginseng medium. Compound 1 showed anti-acetylcholinesterase activity with the inhibition ratio of 38.8% at 50 muM. Compound 2 indicated antimicrobial activities against Fusarium Solani, F. oxysporum, and Escherichia coli with MICs at 128 mug/mL. RG is therefore a promising activator in production of novel microbial metabolite. |
| PubMedSearch : Wang_2019_Nat.Prod.Res__1 |
| PubMedID: 31111733 |
Wang BY, Yang YB, Yang XQ, Zhu CH, Yang S, Xu TT, Wang XY, Tan NH, Zhou H, Ding ZT (2019)
Inducing secondary metabolite production from Daldinia eschscholzii JC-15 by red ginseng medium
Nat Prod Res
:1
Wang BY, Yang YB, Yang XQ, Zhu CH, Yang S, Xu TT, Wang XY, Tan NH, Zhou H, Ding ZT (2019)
Nat Prod Res
:1