| Title : Scocycamides, a Pair of Macrocyclic Dicaffeoylspermidines with Butyrylcholinesterase Inhibition and Antioxidation Activity from the Roots of Scopolia tangutica - Wang_2020_Org.Lett_22_8240 |
| Author(s) : Wang JX , Zhao YP , Du NN , Han Y , Li H , Wang R , Xu Y , Liu YF , Liang XM |
| Ref : Org Lett , 22 :8240 , 2020 |
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Abstract :
A pair of new macrocyclic spermidine alkaloids, (+)-(S)-scocycamide and (-)-(R)-scocycamide, were isolated from the roots of Scopolia tangutica. Their structures were established by extensive spectroscopic data, electronic circular dichroism analyses, and chemical synthesis. They featured a unique 6/18 fused bicyclic framework with spermidine and catechol units, representing a new subtype of natural spermidine alkaloids. A plausible biosynthetic pathway was also proposed. They inhibited butyrylcholinesterase and exhibited antioxidant capacity, suggesting beneficial constituents against Alzheimer's disease and oxidation. |
| PubMedSearch : Wang_2020_Org.Lett_22_8240 |
| PubMedID: 33021797 |
Wang JX, Zhao YP, Du NN, Han Y, Li H, Wang R, Xu Y, Liu YF, Liang XM (2020)
Scocycamides, a Pair of Macrocyclic Dicaffeoylspermidines with Butyrylcholinesterase Inhibition and Antioxidation Activity from the Roots of Scopolia tangutica
Org Lett
22 :8240
Wang JX, Zhao YP, Du NN, Han Y, Li H, Wang R, Xu Y, Liu YF, Liang XM (2020)
Org Lett
22 :8240