| Title : Secoyanhusamine A, an Oxidatively Ring-Opened Isoquinoline Inner Salt From Corydalis yanhusuo - Wang_2021_Front.Chem_9_831173 |
| Author(s) : Wang L , Xia H , Wu Y , Wang Y , Lin P , Lin S |
| Ref : Front Chem , 9 :831173 , 2021 |
| Abstract : Secoyanhusamine A (1), a rare rearranged seco-isoquinoline alkaloid derived from ring oxidative cleavage, was isolated from an aqueous extract of Corydalis yanhusuo tubers, together with its biosynthetic precursor dehydrocorybulbine (2). Secoyanhusamine A (1) was the first example of a highly oxidized isoquinoline inner salt resulting in a 5-(2-azanylethyl)-2-carboxylate-4-oxo-4H-pyran ring system. The biosynthetic pathway of 1 was also postulated. Secoyanhusamine A (1) exhibited potent inhibition against acetylcholinesterase (AChE) with an IC(50) value of 0.81 +/- 0.13 microM. Molecular simulation docking demonstrated that 1 created a strong interaction with the Asp-74 residue of AChE via attractive charge of the quaternary nitrogen. |
| ESTHER : Wang_2021_Front.Chem_9_831173 |
| PubMedSearch : Wang_2021_Front.Chem_9_831173 |
| PubMedID: 35178381 |
Wang L, Xia H, Wu Y, Wang Y, Lin P, Lin S (2021)
Secoyanhusamine A, an Oxidatively Ring-Opened Isoquinoline Inner Salt From Corydalis yanhusuo
Front Chem
9 :831173
Wang L, Xia H, Wu Y, Wang Y, Lin P, Lin S (2021)
Front Chem
9 :831173