| Title : Penisimplicins A and B: Novel Polyketide-Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5 - Wang_2024_Molecules_29_613 |
| Author(s) : Wang QY , Gao Y , Yao JN , Zhou L , Chen HP , Liu JK |
| Ref : Molecules , 29 :613 , 2024 |
|
Abstract :
In this study, two previously undescribed nitrogen-containing compounds, penisimplicins A (1) and B (2), were isolated from Penicillium simplicissimum JXCC5. The structures of 1 and 2 were elucidated on the basis of comprehensive spectroscopic data analysis, including 1D and 2D NMR and HRESIMS data. The absolute configuration of 2 was determined by Marfey's method, ECD calculation, and DP4+ analysis. Both structures of 1 and 2 feature an unprecedented manner of amino acid-derivatives attaching to a polyketide moiety by C-C bond. The postulated biosynthetic pathways for 1 and 2 were discussed. Additionally, compound 1 exhibited significant acetylcholinesterase inhibitory activity, with IC(50) values of 6.35 microM. |
| PubMedSearch : Wang_2024_Molecules_29_613 |
| PubMedID: 38338359 |
Wang QY, Gao Y, Yao JN, Zhou L, Chen HP, Liu JK (2024)
Penisimplicins A and B: Novel Polyketide-Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5
Molecules
29 :613
Wang QY, Gao Y, Yao JN, Zhou L, Chen HP, Liu JK (2024)
Molecules
29 :613