Title : Effect of denervation during development upon membrane potential and intracellular potassium and sodium activities of skeletal muscle of the rat - Ward_1986_Exp.Neurol_93_261 |
Author(s) : Ward KM , Wareham AC |
Ref : Experimental Neurology , 93 :261 , 1986 |
Abstract :
Potassium and sodium ion-selective microelectrodes were used in vitro to investigate the effect of denervation of fast-twitch skeletal muscle (extensor digitorum longus) at 5 days of age upon subsequent development of the resting membrane potential. Normally, during the first 3 weeks of life the balance of intracellular potassium and sodium changed to elevate potassium and to lower sodium. These changes were reflected in the development of a more hyperpolarized resting membrane. Periods of denervation delayed, or prevented, the changes in ion activities and membrane hyperpolarization from occurring. The results are compared with those found after denervation of adult skeletal muscle. |
PubMedSearch : Ward_1986_Exp.Neurol_93_261 |
PubMedID: 3732462 |
Ward KM, Wareham AC (1986)
Effect of denervation during development upon membrane potential and intracellular potassium and sodium activities of skeletal muscle of the rat
Experimental Neurology
93 :261
Ward KM, Wareham AC (1986)
Experimental Neurology
93 :261