Wareham_1978_Pflugers.Arch_373_225

Reference

Title : Effect of denervation and ouabain on the response of the resting membrane potential of rat skeletal muscle to potassium - Wareham_1978_Pflugers.Arch_373_225
Author(s) : Wareham AC
Ref : Pflugers Arch , 373 :225 , 1978
Abstract :

The effects of denervation and ouabain on the relationship between resting membrane potential (EM) and extracellular potassium concentration were determined for rat soleus (SOL) and extensor digitorum longus (EDL) muscles. At concentrations above 20 mM for both SOL AND EDL fibres the relationship could be described adequately by the Nernst equation. Denervation resulted in reduction of EM and a decrease in the slope of the relationship between EM and potassium concentration. 10(-3) M ouabain produced the same effects as denervation. The results are discussed in relation to the alterations in membrane permeability previously shown to occur as a consequence of denervation. It is concluded that the low EM of denervated muscle is the result of an increase in membrane permeability to sodium.

PubMedSearch : Wareham_1978_Pflugers.Arch_373_225
PubMedID: 567319

Related information

Citations formats

Wareham AC (1978)
Effect of denervation and ouabain on the response of the resting membrane potential of rat skeletal muscle to potassium
Pflugers Arch 373 :225

Wareham AC (1978)
Pflugers Arch 373 :225