Title : APOE-varepsilon4 Carrier Status and Donepezil Response in Patients with Alzheimer's Disease - Waring_2015_J.Alzheimers.Dis_47_137 |
Author(s) : Waring JF , Tang Q , Robieson WZ , King DP , Das U , Dubow J , Dutta S , Marek GJ , Gault LM |
Ref : J Alzheimers Dis , 47 :137 , 2015 |
Abstract :
BACKGROUND: Previous studies have investigated associations between apolipoprotein E (APOE)-varepsilon4 allele status and acetylcholinesterase inhibitor treatment response in patients with Alzheimer's disease. The ability to draw definitive conclusions regarding the effect of APOE-varepsilon4 genotype on treatment response has been hindered by inconsistent results among studies and methodological limitations that restrict interpretation of study findings. OBJECTIVE: To determine whether APOE-varepsilon4 carrier status influences the magnitude of change in 13-item Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) score associated with acetylcholinesterase inhibitor treatment (i.e., donepezil). |
PubMedSearch : Waring_2015_J.Alzheimers.Dis_47_137 |
PubMedID: 26402762 |
Waring JF, Tang Q, Robieson WZ, King DP, Das U, Dubow J, Dutta S, Marek GJ, Gault LM (2015)
APOE-varepsilon4 Carrier Status and Donepezil Response in Patients with Alzheimer's Disease
J Alzheimers Dis
47 :137
Waring JF, Tang Q, Robieson WZ, King DP, Das U, Dubow J, Dutta S, Marek GJ, Gault LM (2015)
J Alzheimers Dis
47 :137