Title : Adolescent exposure to nicotine results in reinforcement enhancement but does not affect adult responding in rats - Weaver_2012_Drug.Alcohol.Depend_125_307 |
Author(s) : Weaver MT , Geier CF , Levin ME , Caggiula AR , Sved AF , Donny EC |
Ref : Drug Alcohol Depend , 125 :307 , 2012 |
Abstract :
BACKGROUND: Adolescence is a period of development associated with a peak in an organism's responsiveness to reward. Epidemiological data indicate that the initiation of smoking is high during adolescence and that earlier age of onset is associated with increased incidence of dependence as adults. In rats, nicotine is known to have primary reinforcing and reinforcement enhancing effects. Although the primary reinforcing effects of nicotine have been demonstrated in adolescent rats (self-administration), less is known about its reinforcement enhancing effects during this period. Moreover, the impact of adolescent nicotine exposure on its reinforcement enhancing effects during adulthood has not yet been examined. The objectives of this study were to assess whether (1) nicotine enhances operant responding for an unconditioned visual reinforcer (VS) in adolescent rats, and (2) exposure to nicotine during adolescence affects responsiveness to the VS in adulthood. |
PubMedSearch : Weaver_2012_Drug.Alcohol.Depend_125_307 |
PubMedID: 22483812 |
Weaver MT, Geier CF, Levin ME, Caggiula AR, Sved AF, Donny EC (2012)
Adolescent exposure to nicotine results in reinforcement enhancement but does not affect adult responding in rats
Drug Alcohol Depend
125 :307
Weaver MT, Geier CF, Levin ME, Caggiula AR, Sved AF, Donny EC (2012)
Drug Alcohol Depend
125 :307