| Title : Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity - Weibel_1987_J.Antibiot.(Tokyo)_40_1081 |
| Author(s) : Weibel EK , Hadvary P , Hochuli E , Kupfer E , Lengsfeld H |
| Ref : J Antibiot (Tokyo) , 40 :1081 , 1987 |
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Abstract :
Lipstatin, a new and very potent inhibitor of pancreatic lipase (the key enzyme of intestinal fat digestion) was isolated from Streptomyces toxytricini. Lipstatin contains a beta-lactone structure that probably accounts for the irreversible lipase inhibition. The IC50 of lipstatin for pancreatic lipase is 0.14 microM. In mice triolein absorption was dose-dependently inhibited by lipstatin, whereas oleic acid was absorbed normally. Other pancreatic enzymes, such as phospholipase A2 and trypsin, were not inhibited even at an inhibitor concentration of 200 microM. |
| PubMedSearch : Weibel_1987_J.Antibiot.(Tokyo)_40_1081 |
| PubMedID: 3680018 |
| Inhibitor | Lipstatin |
Weibel EK, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H (1987)
Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity
J Antibiot (Tokyo)
40 :1081
Weibel EK, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H (1987)
J Antibiot (Tokyo)
40 :1081