Title : The kinetics of acetylcholine turnover in a resting cholinergic nerve terminal and the magnitude of the cytoplasmic compartment - Weiler_1982_J.Neurochem_38_1187 |
Author(s) : Weiler MH , Roed IS , Whittaker VP |
Ref : Journal of Neurochemistry , 38 :1187 , 1982 |
Abstract :
The magnitude of the cytosolic pool of acetylcholine in the cholinergic electromotor nerve terminals of Torpedo marmorata has been calculated to be 22 +/- 3% of the total by comparing the isotopic ratio of acetylcholine with that of choline when slices of electric organ were incubated with 10 microM deuterated choline. The calculation is based on a two-compartment model that assumes the presence, in unstimulated tissue, of a vesicular pool of acetylcholine that does not exchange, under resting conditions, with a second cytosolic pool; the latter, by contrast, is subject to 'futile recycling' and comes into isotopic equilibrium with the tissue choline pool. |
PubMedSearch : Weiler_1982_J.Neurochem_38_1187 |
PubMedID: 7062045 |
Weiler MH, Roed IS, Whittaker VP (1982)
The kinetics of acetylcholine turnover in a resting cholinergic nerve terminal and the magnitude of the cytoplasmic compartment
Journal of Neurochemistry
38 :1187
Weiler MH, Roed IS, Whittaker VP (1982)
Journal of Neurochemistry
38 :1187