| Title : Basal forebrain cholinergic neurons are selectively vulnerable to AMPA\/kainate receptor-mediated neurotoxicity - Weiss_1994_Neurosci_60_659 |
| Author(s) : Weiss JH , Yin HZ , Choi DW |
| Ref : Neuroscience , 60 :659 , 1994 |
| Abstract : We exposed murine basal forebrain neuronal cultures for 24 h to defined concentrations of N-methyl-D-aspartate, kainate or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate, and assessed the resultant degeneration of the cholinergic neuronal subpopulation, as identified by choline acetyltransferase immunocytochemistry and acetylcholinesterase histochemistry. Cholinergic neurons, representing about 0.5% of the total neuronal population, were atypically vulnerable to excitotoxins. Compared to most basal forebrain neurons, they were more vulnerable to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate/kainate receptor-mediated injury and slightly less vulnerable to N-methyl-D-aspartate receptor-mediated injury. The present findings provide quantitative demonstration of a mechanism that preferentially injures basal forebrain cholinergic neurons, and may thus suggest candidate factors pertaining to their loss in disease states like Alzheimer's disease. |
| ESTHER : Weiss_1994_Neurosci_60_659 |
| PubMedSearch : Weiss_1994_Neurosci_60_659 |
| PubMedID: 7523984 |
Weiss JH, Yin HZ, Choi DW (1994)
Basal forebrain cholinergic neurons are selectively vulnerable to AMPA\/kainate receptor-mediated neurotoxicity
Neuroscience
60 :659
Weiss JH, Yin HZ, Choi DW (1994)
Neuroscience
60 :659