| Title : [3H]acetylcholine release from the phrenic nerve is increased or decreased by activation or desensitization of nicotine receptors - Wessler_1987_Eur.J.Pharmacol_135_85 |
| Author(s) : Wessler I , Scheuer B , Kilbinger H |
| Ref : European Journal of Pharmacology , 135 :85 , 1987 |
|
Abstract :
Nicotinic agonists (nicotine, 1,1-dimethyl-4-phenylpiperazinium (DMPP) increased [3H]acetylcholine release when the pre-exposure time was short (20 s). This effect was antagonized by pretreatment with d-tubocurarine (d-TC), which indicates a receptor-mediated effect. After a longer pre-exposure time (3 min) 10 microM nicotine significantly decreased the evoked [3H]acetylcholine release, probably because desensitization of the nicotine autoreceptors had abolished the nicotinic autofacilitation of transmitter release. |
| PubMedSearch : Wessler_1987_Eur.J.Pharmacol_135_85 |
| PubMedID: 3569426 |
Wessler I, Scheuer B, Kilbinger H (1987)
[3H]acetylcholine release from the phrenic nerve is increased or decreased by activation or desensitization of nicotine receptors
European Journal of Pharmacology
135 :85
Wessler I, Scheuer B, Kilbinger H (1987)
European Journal of Pharmacology
135 :85