West_2011_Chem.Commun.(Camb)_47_5166

Reference

Title : Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads - West_2011_Chem.Commun.(Camb)_47_5166
Author(s) : West NP , Cergol KM , Xue M , Randall EJ , Britton WJ , Payne RJ
Ref : Chem Commun (Camb) , 47 :5166 , 2011
Abstract :

The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target.

PubMedSearch : West_2011_Chem.Commun.(Camb)_47_5166
PubMedID: 21384024
Gene_locus related to this paper: myctu-Rv3802c

Related information

Citations formats

West NP, Cergol KM, Xue M, Randall EJ, Britton WJ, Payne RJ (2011)
Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads
Chem Commun (Camb) 47 :5166

West NP, Cergol KM, Xue M, Randall EJ, Britton WJ, Payne RJ (2011)
Chem Commun (Camb) 47 :5166