| Title : Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads - West_2011_Chem.Commun.(Camb)_47_5166 |
| Author(s) : West NP , Cergol KM , Xue M , Randall EJ , Britton WJ , Payne RJ |
| Ref : Chem Commun (Camb) , 47 :5166 , 2011 |
|
Abstract :
The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target. |
| PubMedSearch : West_2011_Chem.Commun.(Camb)_47_5166 |
| PubMedID: 21384024 |
| Gene_locus related to this paper: myctu-Rv3802c |
| Inhibitor | Cpd17-Pyrrolidine-THL-derivative |
| Gene_locus | myctu-Rv3802c |
West NP, Cergol KM, Xue M, Randall EJ, Britton WJ, Payne RJ (2011)
Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads
Chem Commun (Camb)
47 :5166
West NP, Cergol KM, Xue M, Randall EJ, Britton WJ, Payne RJ (2011)
Chem Commun (Camb)
47 :5166