Weston_1985_Behav.Brain.Res_18_71

Reference

Title : Application of acetylcholinesterase to the substantia nigra induces stereotypy in rats - Weston_1985_Behav.Brain.Res_18_71
Author(s) : Weston J , Greenfield SA
Ref : Behavioural Brain Research , 18 :71 , 1985
Abstract :

In the substantia nigra, acetylcholinesterase may have a non-cholinergic function. Previous work suggests that release of acetylcholinesterase locally in the substantia nigra leads to a net increase in dopaminergic activity in the ipsilateral striatum. To investigate this hypothesis, acetylcholinesterase was microinjected bilaterally into the substantiae nigrae of awake rats and stereotyped behaviour used as an indication of increased dopaminergic activity in the striatum. Acetylcholinesterase increased stereotypy in rats, while butyrylcholinesterase and the vehicle, distilled water, were ineffective. The functional significance of acetylcholinesterase in the substantiae nigrae of freely moving animals is discussed in the light of its apparent association with dopaminergic rather than cholinergic systems.

PubMedSearch : Weston_1985_Behav.Brain.Res_18_71
PubMedID: 3911982

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Citations formats

Weston J, Greenfield SA (1985)
Application of acetylcholinesterase to the substantia nigra induces stereotypy in rats
Behavioural Brain Research 18 :71

Weston J, Greenfield SA (1985)
Behavioural Brain Research 18 :71