| Title : Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels - Widagdo_2016_J.Virol_90_4838 |
| Author(s) : Widagdo W , Raj VS , Schipper D , Kolijn K , van Leenders G , Bosch BJ , Bensaid A , Segales J , Baumgartner W , Osterhaus A , Koopmans MP , van den Brand JMA , Haagmans BL |
| Ref : J Virol , 90 :4838 , 2016 |
|
Abstract :
Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission. |
| PubMedSearch : Widagdo_2016_J.Virol_90_4838 |
| PubMedID: 26889022 |
Widagdo W, Raj VS, Schipper D, Kolijn K, van Leenders G, Bosch BJ, Bensaid A, Segales J, Baumgartner W, Osterhaus A, Koopmans MP, van den Brand JMA, Haagmans BL (2016)
Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels
J Virol
90 :4838
Widagdo W, Raj VS, Schipper D, Kolijn K, van Leenders G, Bosch BJ, Bensaid A, Segales J, Baumgartner W, Osterhaus A, Koopmans MP, van den Brand JMA, Haagmans BL (2016)
J Virol
90 :4838