| Title : Fractionation of synaptophysin-containing vesicles from rat brain and cultured PC12 pheochromocytoma cells - Wiedenmann_1988_FEBS.Lett_240_71 |
| Author(s) : Wiedenmann B , Rehm H , Knierim M , Becker CM |
| Ref : FEBS Letters , 240 :71 , 1988 |
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Abstract :
Synaptophysin is a transmembrane glycoprotein of neuroendocrine vesicles. Its content and distribution in subcellular fractions from cultured PC12 cells, rat brain and bovine adrenal medulla were determined by a sensitive dot immunoassay. Synaptophysin-containing fractions appeared as monodispersed populations similar to synaptic vesicles in density and size distribution. Membranes from synaptic vesicles contained approximately 100-times more synaptophysin than chromaffin granules. In conclusion, synaptophysin is located almost exclusively in vesicles of brain and PC12 cells which are distinct from dense core granules. |
| PubMedSearch : Wiedenmann_1988_FEBS.Lett_240_71 |
| PubMedID: 3142795 |
Wiedenmann B, Rehm H, Knierim M, Becker CM (1988)
Fractionation of synaptophysin-containing vesicles from rat brain and cultured PC12 pheochromocytoma cells
FEBS Letters
240 :71
Wiedenmann B, Rehm H, Knierim M, Becker CM (1988)
FEBS Letters
240 :71