Witzemann_1991_FEBS.Lett_282_259

Reference

Title : Differential regulation of MyoD and myogenin mRNA levels by nerve induced muscle activity - Witzemann_1991_FEBS.Lett_282_259
Author(s) : Witzemann V , Sakmann B
Ref : FEBS Letters , 282 :259 , 1991
Abstract :

The levels of mRNAs coding for the myogenic factors MyoD and myogenin were measured during synapse formation in developing muscle and in adult muscle, after denervation and reinnervation and after muscle paralysis induced by blocking of neuromuscular transmission by neurotoxins known to alter the density and localization of synaptic proteins such as the acetylcholine receptor (AChR). The mRNA levels of both factors depend on usage of the neuromuscular synapses, but they change to different extents. Myogenin mRNA levels decrease drastically with innervation and increase strongly following blocking of transmission whereas the level of MyoD mRNA showed only a small decrease in response to innervation, denervation or muscle paralysis by neurotoxins. Neither mRNA showed a synapse-related cellular distribution. The results suggest that nerve-induced electrical muscle activity determines the cellular ratio of MyoD and myogenin mRNAs in adult muscle.

PubMedSearch : Witzemann_1991_FEBS.Lett_282_259
PubMedID: 1645281

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Citations formats

Witzemann V, Sakmann B (1991)
Differential regulation of MyoD and myogenin mRNA levels by nerve induced muscle activity
FEBS Letters 282 :259

Witzemann V, Sakmann B (1991)
FEBS Letters 282 :259