Wojtasek_1996_Biochem.Biophys.Res.Commun_220_323

Reference

Title : An insect juvenile hormone-specific epoxide hydrolase is related to vertebrate microsomal epoxide hydrolases. - Wojtasek_1996_Biochem.Biophys.Res.Commun_220_323
Author(s) : Wojtasek H , Prestwich GD
Ref : Biochemical & Biophysical Research Communications , 220 :323 , 1996
Abstract :

We describe the first cDNA sequence encoding a juvenile hormone-specific epoxide hydrolase from an insect. A full-length cDNA clone revealed a 462-amino-acid open reading frame encoding an amino acid sequence with 44% identity and 64% similarity to human microsomal epoxide hydrolase. All residues in the catalytic triad (residues Asp227-His428-Asp350 in the M. sexta protein) were present, as was the conserved Trp154 corresponding to the oxyanion hole. The surprising similarity of insect juvenile hormone epoxide hydrolase to vertebrate microsomal epoxide hydrolases, coupled with the ancient lineage of the epoxide hydrolases and haloalkane dehalogenases, suggests that this catabolic enzyme evolved from an original ubiquitous detoxication function to a more recent role in hormonal regulation.

PubMedSearch : Wojtasek_1996_Biochem.Biophys.Res.Commun_220_323
PubMedID: 8645304
Gene_locus related to this paper: manse-hyep

Related information

Gene_locus manse-hyep

Citations formats

Wojtasek H, Prestwich GD (1996)
An insect juvenile hormone-specific epoxide hydrolase is related to vertebrate microsomal epoxide hydrolases.
Biochemical & Biophysical Research Communications 220 :323

Wojtasek H, Prestwich GD (1996)
Biochemical & Biophysical Research Communications 220 :323