Wopara_2021_Heliyon_7_e08454

Reference

Title : Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine - Wopara_2021_Heliyon_7_e08454
Author(s) : Wopara I , Adebayo OG , Umoren EB , Aduema W , Iwueke AV , Etim OE , Pius EA , James WB , Wodo J
Ref : Heliyon , 7 :e08454 , 2021
Abstract :

Overuse or overconsumption of food additive or colorant cannot be ignored in our society and there are several reports of it harmful effect on the body system. This study investigated the toxicity effect of tartrazine and erythrosine (ET, 50:50) on neurobehavioral alteration, striatal oxido-nitrosative and pro-inflammatory stress and striatal acetylcholinesterase activity in experimental rat model. Rats were co-exposed to ET (2 mg/kg, 6 mg/kg and 10 mg/kg) and distilled water (control), p.o for 6 weeks. The change in neurobehavioral function (Open field test, Forced swimming test and Tail suspension test), Lipid peroxidation (Malonaldehyde, MDA), Antioxidants (Glutathione, GSH; Catalase, CAT) Nitrite, Pro-inflammatory cytokine (Tumor necrosis factor-alpha, TNF-alpha) and Acetylcholinesterase (AChE) activity were evaluated. Results showed significant decrease in neurobehavioral functions after co-exposure to ET. Moreover, there were significant increase in MDA and Nitrite level, significant decrease in the concentration of GSH and CAT and a significant increase TNF-alpha concentration and AChE activity after co-exposure to ET. Oral co-exposure to tartrazine and erythrosine induced decrease in locomotion and exploration, increase anxiety and depression-like behavior and altered the cholinergic system through upregulation of oxido-nitrosative stress, pro-inflammatory cytokine and acetylcholinesterase activity.

PubMedSearch : Wopara_2021_Heliyon_7_e08454
PubMedID: 34888423

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Citations formats

Wopara I, Adebayo OG, Umoren EB, Aduema W, Iwueke AV, Etim OE, Pius EA, James WB, Wodo J (2021)
Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine
Heliyon 7 :e08454

Wopara I, Adebayo OG, Umoren EB, Aduema W, Iwueke AV, Etim OE, Pius EA, James WB, Wodo J (2021)
Heliyon 7 :e08454