| Title : Bioactive neolignans and lignans from the roots of Paeonia lactiflora - Xia_2022_Chin.J.Nat.Med_20_210 |
| Author(s) : Xia H , Zhang JF , Wang LY , Xia GY , Wang YN , Wu YZ , Lin PC , Xiong L , Lin S |
| Ref : Chin J Nat Med , 20 :210 , 2022 |
|
Abstract :
Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC(50) value of 7.28 +/- 0.94 micromol.(-1). |
| PubMedSearch : Xia_2022_Chin.J.Nat.Med_20_210 |
| PubMedID: 35369965 |
Xia H, Zhang JF, Wang LY, Xia GY, Wang YN, Wu YZ, Lin PC, Xiong L, Lin S (2022)
Bioactive neolignans and lignans from the roots of Paeonia lactiflora
Chin J Nat Med
20 :210
Xia H, Zhang JF, Wang LY, Xia GY, Wang YN, Wu YZ, Lin PC, Xiong L, Lin S (2022)
Chin J Nat Med
20 :210