| Title : Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176 - Xin_2013_PLoS.One_8_e63874 |
| Author(s) : Xin L , Yamujala R , Wang Y , Wang H , Wu WH , Lawton MA , Long C , Di R |
| Ref : PLoS ONE , 8 :e63874 , 2013 |
|
Abstract :
The limited symptom relief and side effects of current Alzheimer's disease (AD) medications warrant urgent discovery and study of new anti-AD agents. The "cholinergic hypothesis" of AD prompts us to search for plant-derived acetylcholineesterase (AChE) inhibitors such as galanthamine that has been licensed in Europe for AD treatment. We used the unique amyloid beta-expressing transgenic C. elegans CL4176, which exhibits paralysis when human Abeta1-42 is induced, to study two natural benzylphenethylamine alkaloids isolated from Lycoris radiata (L' Her.) Herb, galanthamine and haemanthidine, and their synthetic derivatives 1,2-Di-O-acetyllycorine and 1-O-acetyllycorine for their anti-paralysis effects. Our data indicate that these Lycoris compounds effectively delay the paralysis of CL4176 worms upon temperature up-shift, and prolong the lives of these transgenic worms. Lycoris compounds were shown to significantly inhibit the gene expression of ace-1 and ace-2. Additionally, the Lycoris compounds may modulate inflammatory and stress-related gene expressions to combat the Abeta-toxicity in C. elegans. |
| PubMedSearch : Xin_2013_PLoS.One_8_e63874 |
| PubMedID: 23675513 |
Xin L, Yamujala R, Wang Y, Wang H, Wu WH, Lawton MA, Long C, Di R (2013)
Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176
PLoS ONE
8 :e63874
Xin L, Yamujala R, Wang Y, Wang H, Wu WH, Lawton MA, Long C, Di R (2013)
PLoS ONE
8 :e63874