| Title : Unlike 2-deoxy-D-glucose, 3-O-methyl-D-glucose does not induce long-term potentiation in rat hippocampal slices - Xu_2001_Brain.Res_895_250 |
| Author(s) : Xu YZ , Krnjevic K |
| Ref : Brain Research , 895 :250 , 2001 |
|
Abstract :
Equimolar replacement of 10 mM glucose by 2-deoxy-D-glucose (2-DG) causes substantial depression followed by a sharp and sustained potentiation of CA1 field EPSPs. In the present experiments, similar applications of 3-O-methyl-D-glucose, which is also taken up by cells but is not phosphorylated, had only a weak blocking action and elicited no potentiation. Possible explanations for the marked effects of 2-DG include a more rapid block of glycolysis and the production of phosphorylated derivatives of 2-DG. |
| PubMedSearch : Xu_2001_Brain.Res_895_250 |
| PubMedID: 11259785 |
Xu YZ, Krnjevic K (2001)
Unlike 2-deoxy-D-glucose, 3-O-methyl-D-glucose does not induce long-term potentiation in rat hippocampal slices
Brain Research
895 :250
Xu YZ, Krnjevic K (2001)
Brain Research
895 :250