| Title : Bactericidal Dendritic Polycation Cloaked with Stealth Material via Lipase-Sensitive Intersegment Acquires Neutral Surface Charge without Losing Membrane-Disruptive Activity - Xu_2015_ACS.Appl.Mater.Interfaces_7_27602 |
| Author(s) : Xu L , He C , Hui L , Xie Y , Li JM , He WD , Yang L |
| Ref : ACS Appl Mater Interfaces , 7 :27602 , 2015 |
|
Abstract :
Net cationicity of membrane-disruptive antimicrobials is necessary for their activity but may elicit immune attack when administered intravenously. By cloaking a dendritic polycation (G2) with poly(caprolactone-b-ethylene glycol) (PCL-b-PEG), we obtain a nanoparticle antimicrobial, G2-g-(PCL-b-PEG), which exhibits neutral surface charge but kills >99.9% of inoculated bacterial cells at >=8 microg/mL. The observed activity may be attributed PCL's responsive degradation by bacterial lipase and the consequent exposure of the membrane-disruptive, bactericidal G2 core. Moreover, G2-g-(PCL-b-PEG) exhibits good colloidal stability in the presence of serum and insignificant hemolytic toxicity even at <=2048 microg/mL. suggesting good blood compatibility required for intravenous administration. |
| PubMedSearch : Xu_2015_ACS.Appl.Mater.Interfaces_7_27602 |
| PubMedID: 26632646 |
Xu L, He C, Hui L, Xie Y, Li JM, He WD, Yang L (2015)
Bactericidal Dendritic Polycation Cloaked with Stealth Material via Lipase-Sensitive Intersegment Acquires Neutral Surface Charge without Losing Membrane-Disruptive Activity
ACS Appl Mater Interfaces
7 :27602
Xu L, He C, Hui L, Xie Y, Li JM, He WD, Yang L (2015)
ACS Appl Mater Interfaces
7 :27602