Title : Novel chaetospirolactone and orsellide F from an endophytic fungus Chaetomium sp - Xu_2017_J.Asian.Nat.Prod.Res__1 |
Author(s) : Xu QL , Xiao YS , Shen Y , Wu HM , Zhang X , Deng XZ , Wang TT , Li W , Tan RX , Jiao RH , Ge HM |
Ref : J Asian Nat Prod Res , :1 , 2017 |
Abstract :
Chaetospirolactone (1), a novel spiro-lactone bearing a rare 1-oxaspiro [4.4] non-7-ene-2,6-dione skeleton, and orsellide F (2), together with six known compounds (3-8), were isolated from an endophytic fungus Chaetomium sp. NF00754. Their structures were determined by interpretation of spectroscopic data. The absolute configurations of 1 and 2 were established by analysis of single X-ray crystallographic data and CD spectra. Compounds 3, 4, and 6 showed moderate acetylcholinesterase inhibitory activity with IC50 values of 7.34, 5.19, and 7.67 muM, respectively. |
PubMedSearch : Xu_2017_J.Asian.Nat.Prod.Res__1 |
PubMedID: 28478698 |
Xu QL, Xiao YS, Shen Y, Wu HM, Zhang X, Deng XZ, Wang TT, Li W, Tan RX, Jiao RH, Ge HM (2017)
Novel chaetospirolactone and orsellide F from an endophytic fungus Chaetomium sp
J Asian Nat Prod Res
:1
Xu QL, Xiao YS, Shen Y, Wu HM, Zhang X, Deng XZ, Wang TT, Li W, Tan RX, Jiao RH, Ge HM (2017)
J Asian Nat Prod Res
:1