Xu_2018_Mediators.Inflamm_2018_5201652

Reference

Title : Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients - Xu_2018_Mediators.Inflamm_2018_5201652
Author(s) : Xu L , Zhu B , Huang Y , Yang Z , Sun J , Xu Y , Zheng J , Kinloch S , Yin MT , Weng H , Wu N
Ref : Mediators Inflamm , 2018 :5201652 , 2018
Abstract :

Background: Butyrylcholinesterase (BChE) is synthesized mainly in the liver and an important marker in many infectious/inflammatory diseases, but its role in acquired immunodeficiency syndrome (AIDS) patients is not clear. We wished to ascertain if BChE level is associated with the progression/prognosis of AIDS patients. Methods: BChE levels (in U/L) were measured in 505 patients; <4500 was defined as "low" and >/=4500 as "normal." Associations between BChE level and CD4 count, WHO stage, body mass index (BMI), C-reactive protein (CRP) level, and duration of hospitalization were assessed. Kaplan-Meier curves and Cox proportional hazards model were used to assess associations between low BChE levels and mortality, after adjustment for age, CD4 count, WHO stage, and laboratory parameters. Results: A total of 129 patients (25.5%) had a lower BChE level. BChE was closely associated with CD4 count, WHO stage, CRP level, and BMI (all P < 0.001). Eighty-four patients (16.6%) died in the first year of follow-up. One-year survival was 64.5 +/- 4.5% for patients with low BChE and 87.6 +/- 1.8% for those with normal BChE (log-rank, P < 0.001). After adjustment for sex, age, BMI, WHO stage, and CD4 count, as well as serum levels of hemoglobin, sodium, and albumin, the hazard ratio was 1.8 (95% confidence interval, 1.0-3.2) for patients with a low BChE compared with those with a normal BChE (P = 0.035). Conclusion: BChE level is associated with HIV/AIDS severity and is an independent risk factor for increased mortality in AIDS patients.

PubMedSearch : Xu_2018_Mediators.Inflamm_2018_5201652
PubMedID: 29736152

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Citations formats

Xu L, Zhu B, Huang Y, Yang Z, Sun J, Xu Y, Zheng J, Kinloch S, Yin MT, Weng H, Wu N (2018)
Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients
Mediators Inflamm 2018 :5201652

Xu L, Zhu B, Huang Y, Yang Z, Sun J, Xu Y, Zheng J, Kinloch S, Yin MT, Weng H, Wu N (2018)
Mediators Inflamm 2018 :5201652