| Title : The muscarinic receptor of rat pituitary GH3 cells is coupled with adenylate cyclase inhibition, but not with phosphoinositide turnover - Yagisawa_1988_Biochem.Pharmacol_37_2675 |
| Author(s) : Yagisawa H , Simmonds SH , Hawthorne JN |
| Ref : Biochemical Pharmacology , 37 :2675 , 1988 |
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Abstract :
The effects of muscarinic stimulation on cyclic AMP accumulation and on basal and thyrotropin-releasing hormone (TRH)-induced phosphoinositide turnover have been studied in rat pituitary GH3 tumour cells. Carbachol produced a dose-dependent atropine-sensitive inhibition of basal cyclic AMP accumulation. It had no effect on basal or TRH-stimulated production of inositol phosphates. The majority of the muscarinic receptors had a low affinity (Ki 0.22 microM) for pirenzepine and can be classified as M2 type, inhibiting adenylate cyclase but having no links with phosphoinositide metabolism. |
| PubMedSearch : Yagisawa_1988_Biochem.Pharmacol_37_2675 |
| PubMedID: 2455524 |
Yagisawa H, Simmonds SH, Hawthorne JN (1988)
The muscarinic receptor of rat pituitary GH3 cells is coupled with adenylate cyclase inhibition, but not with phosphoinositide turnover
Biochemical Pharmacology
37 :2675
Yagisawa H, Simmonds SH, Hawthorne JN (1988)
Biochemical Pharmacology
37 :2675