| Title : Interspecific comparisons reveal conserved features of the Drosophila Toll protein - Yamagata_1994_Gene_139_223 |
| Author(s) : Yamagata M , Merlie JP , Sanes JR |
| Ref : Gene , 139 :223 , 1994 |
| Abstract : The Toll gene of Drosophila melanogaster produces a transmembrane cell adhesion protein that is required to establish the dorso-ventral axis of the embryo. The Toll protein's extracellular domain contains Leu-rich repeats (LRR), implicated in intermolecular interactions, and its large intracellular domain transduces a signal that eventually reaches the nucleus. Here, we report amino-acid (aa) sequences encoded by the Toll genes of D. pseudoobscura and D. virilis, and two distinct Toll-like genes of the grasshopper, Schistocerca americana. Interspecific comparisons show a Toll-specific subfamily of LRR, and a strikingly high degree of conservation in the cytoplasmic domain. Interestingly, many aa residues conserved among the insect Toll-like cytoplasmic domains are also conserved in mammalian and avian type-I interleukin-1 receptors and the hypothetical product of a transcript, MyD88, found in murine myeloid cells. Thus, we identify a set of conserved aa in the cytoplasmic domain which might be used in a signal-transduction pathway shared by invertebrates and vertebrates. |
| ESTHER : Yamagata_1994_Gene_139_223 |
| PubMedSearch : Yamagata_1994_Gene_139_223 |
| PubMedID: 8112609 |
Yamagata M, Merlie JP, Sanes JR (1994)
Interspecific comparisons reveal conserved features of the Drosophila Toll protein
Gene
139 :223
Yamagata M, Merlie JP, Sanes JR (1994)
Gene
139 :223