| Title : Enzymatic resolution and evaluation of enantiomers of cis-5'-hydroxythalidomide - Yamamoto_2008_Org.Biomol.Chem_6_1540 |
| Author(s) : Yamamoto T , Shibata N , Takashima M , Nakamura S , Toru T , Matsunaga N , Hara H |
| Ref : Org Biomol Chem , 6 :1540 , 2008 |
|
Abstract :
The straightforward synthesis of both enantiomers of cis-5'-hydroxythalidomide, a major metabolite of thalidomide, has been accomplished by enzymatic kinetic resolution of a racemic substrate catalyzed by Pseudomonas stutzeri lipase TL. cis-5'-Hydroxythalidomide shows resistance to racemization (and epimerization) at physiological pH. A tube formation assay to assess the ability to inhibit angiogenesis revealed that cis-5'-hydroxythalidomides are inactive. |
| PubMedSearch : Yamamoto_2008_Org.Biomol.Chem_6_1540 |
| PubMedID: 18421383 |
Yamamoto T, Shibata N, Takashima M, Nakamura S, Toru T, Matsunaga N, Hara H (2008)
Enzymatic resolution and evaluation of enantiomers of cis-5'-hydroxythalidomide
Org Biomol Chem
6 :1540
Yamamoto T, Shibata N, Takashima M, Nakamura S, Toru T, Matsunaga N, Hara H (2008)
Org Biomol Chem
6 :1540