| Title : Synthesis of (-)-homogalanthamine from naltrexone - Yamamoto_2011_J.Org.Chem_76_2257 |
| Author(s) : Yamamoto N , Fujii H , Imaide S , Hirayama S , Nemoto T , Inokoshi J , Tomoda H , Nagase H |
| Ref : J Org Chem , 76 :2257 , 2011 |
|
Abstract :
Acetylcholinesterase inhibitor (-)-homogalanthamine 3 was synthesized from u opioid antagonist naltrexone (2) in 16% total yield. The synthesis features Grob fragmentation as a key reaction, which was especially accelerated in the presence of 15-crown-5 |
| PubMedSearch : Yamamoto_2011_J.Org.Chem_76_2257 |
| PubMedID: 21381712 |
Yamamoto N, Fujii H, Imaide S, Hirayama S, Nemoto T, Inokoshi J, Tomoda H, Nagase H (2011)
Synthesis of (-)-homogalanthamine from naltrexone
J Org Chem
76 :2257
Yamamoto N, Fujii H, Imaide S, Hirayama S, Nemoto T, Inokoshi J, Tomoda H, Nagase H (2011)
J Org Chem
76 :2257