| Title : Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis - Yan_2018_Org.Lett_20_5918 |
| Author(s) : Yan X , Chen JJ , Adhikari A , Teijaro CN , Ge H , Crnovcic I , Chang CY , Annaval T , Yang D , Rader C , Shen B |
| Ref : Org Lett , 20 :5918 , 2018 |
|
Abstract :
Comparative analyses of the four known anthraquinone-fused enediynes biosynthetic gene clusters identified four genes, tnmE6, tnmH, tnmL, and tnmQ, unique to the tnm gene cluster. Larger scale fermentation of both the S. sp. CB03234 wild-type and the delta tnmH and delta tnmL mutant strains resulted in the characterization of 20 new tiancimycin (TNM) congeners, including five enediynes. These findings enabled a proposal for the late stage of TNM biosynthesis featuring an intermediate possibly common for all anthraquinone-fused enediynes. |
| PubMedSearch : Yan_2018_Org.Lett_20_5918 |
| PubMedID: 30212211 |
| Substrate | Tiancimycin-B |
Yan X, Chen JJ, Adhikari A, Teijaro CN, Ge H, Crnovcic I, Chang CY, Annaval T, Yang D, Rader C, Shen B (2018)
Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis
Org Lett
20 :5918
Yan X, Chen JJ, Adhikari A, Teijaro CN, Ge H, Crnovcic I, Chang CY, Annaval T, Yang D, Rader C, Shen B (2018)
Org Lett
20 :5918