| Title : An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure-activity correlations - Yang_2012_Nat.Prod.Res_26_387 |
| Author(s) : Yang ZD , Zhang X , Du J , Ma ZJ , Guo F , Li S , Yao XJ |
| Ref : Nat Prod Res , 26 :387 , 2012 |
| Abstract : N-methylasimilobine (1), a new-found strong acetylcholinesterase (AChE) inhibitor, along with two weakly active aporphine alkaloids, nuciferine (2) and nornuciferine (3) were separated from Nelumbo nucifera. N-methylasimilobine (1) inhibited 50% of AChE activity at the concentrations of 1.5 +/- 0.2 microg mL(-1) when the standard IC(50) value of Physostigmine was 0.013 +/- 0.002 microg mL(-1). The mode of AChE inhibition by 1 was reversible and non-competitive. In addition, molecular modelling was performed to explore the binding mode of inhibitor 1 at the active site of AChE. |
| ESTHER : Yang_2012_Nat.Prod.Res_26_387 |
| PubMedSearch : Yang_2012_Nat.Prod.Res_26_387 |
| PubMedID: 21732870 |
Yang ZD, Zhang X, Du J, Ma ZJ, Guo F, Li S, Yao XJ (2012)
An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure-activity correlations
Nat Prod Res
26 :387
Yang ZD, Zhang X, Du J, Ma ZJ, Guo F, Li S, Yao XJ (2012)
Nat Prod Res
26 :387