| Title : Lipoprotein lipase deficiency leads to alpha-synuclein aggregation and ubiquitin C-terminal hydrolase L1 reduction - Yang_2015_Neurosci_290_1 |
| Author(s) : Yang H , Zhou T , Wang H , Liu T , Ueda K , Zhan R , Zhao L , Tong Y , Tian X , Zhang T , Jin Y , Han X , Li Z , Zhao Y , Guo X , Xiao W , Fan D , Liu G , Chui D |
| Ref : Neuroscience , 290 :1 , 2015 |
|
Abstract :
We have previously reported that presynaptic dysfunction and cognitive decline have been found in lipoprotein lipase (LPL) deficient mice, but the mechanism remains to be elucidated. Accumulating evidence supported that alpha-synuclein (alpha-syn) and ubiquitin C-terminal hydrolase L1 (UCHL1) are required for normal synaptic and cognitive function. In this study, we found that alpha-syn aggregated and the expression of UCHL1 decreased in the brain of LPL deficient mice. Reduction of UCHL1 was resulted from nuclear retention of DNA cytosine-5-methyltransferase 1 in LPL knockout mice. Reverse changes were found in cultured cells overexpressing LPL. Furthermore, deficiency of LPL increased ubiquitination of alpha-syn. These results indicated that aggregation of alpha-syn and reduction of UCHL1 expression in LPL-deficient mice may affect synaptic function. |
| PubMedSearch : Yang_2015_Neurosci_290_1 |
| PubMedID: 25595992 |
Yang H, Zhou T, Wang H, Liu T, Ueda K, Zhan R, Zhao L, Tong Y, Tian X, Zhang T, Jin Y, Han X, Li Z, Zhao Y, Guo X, Xiao W, Fan D, Liu G, Chui D (2015)
Lipoprotein lipase deficiency leads to alpha-synuclein aggregation and ubiquitin C-terminal hydrolase L1 reduction
Neuroscience
290 :1
Yang H, Zhou T, Wang H, Liu T, Ueda K, Zhan R, Zhao L, Tong Y, Tian X, Zhang T, Jin Y, Han X, Li Z, Zhao Y, Guo X, Xiao W, Fan D, Liu G, Chui D (2015)
Neuroscience
290 :1