| Title : Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria - Yang_2017_J.Asian.Nat.Prod.Res_19_732 |
| Author(s) : Yang M , Liang LF , Wang T , Wang HY , Liu HL , Guo YW |
| Ref : J Asian Nat Prod Res , 19 :732 , 2017 |
|
Abstract :
A new brominated polyacetylene, xestonariene I (1), along with three known related analogues (2-4), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and by comparison with literature data. Compound 4 exhibited significant inhibitory activity against pancreatic lipase, which plays a key role in preventing obesity, with an IC50 value of 0.61 muM, being comparable to that of the positive control orlistat (IC50 = 0.78 muM). |
| PubMedSearch : Yang_2017_J.Asian.Nat.Prod.Res_19_732 |
| PubMedID: 28152617 |
Yang M, Liang LF, Wang T, Wang HY, Liu HL, Guo YW (2017)
Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria
J Asian Nat Prod Res
19 :732
Yang M, Liang LF, Wang T, Wang HY, Liu HL, Guo YW (2017)
J Asian Nat Prod Res
19 :732