| Title : Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents - Yang_2019_J.Enzyme.Inhib.Med.Chem_34_651 |
| Author(s) : Yang J , Zhang P , Hu Y , Liu T , Sun J , Wang X |
| Ref : J Enzyme Inhib Med Chem , 34 :651 , 2019 |
|
Abstract :
Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activity, including cholinesterase inhibitory activity, monoamine oxidase inhibitory activity, and antioxidant activity were investigated. Most of the compounds exhibited high activity; therefore 3-arylcoumarin compounds have the potential as drug candidates for the treatment of Alzheimer's disease. |
| PubMedSearch : Yang_2019_J.Enzyme.Inhib.Med.Chem_34_651 |
| PubMedID: 30746966 |
Yang J, Zhang P, Hu Y, Liu T, Sun J, Wang X (2019)
Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
J Enzyme Inhib Med Chem
34 :651
Yang J, Zhang P, Hu Y, Liu T, Sun J, Wang X (2019)
J Enzyme Inhib Med Chem
34 :651